Mechanism of methaemoglobin reduction by human erythrocytes
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چکیده
منابع مشابه
Mechanism of methaemoglobin reduction by human erythrocytes.
The time course of methaemoglobin reduction in human erythrocytes treated with nitrite was studied at pH 7.4, 37 degrees C, in the presence or absence of Methylene Blue, and the changes in methaemoglobin, intermediate haemoglobins and oxyhaemoglobin during the reaction were analysed by isoelectric-focusing on Ampholine/polyacrylamide-gel plates. In both cases, with or without the dye, the inter...
متن کاملThe role of the pentose phosphate pathway in the reduction of methaemoglobin in human erythrocytes.
Tower, D. B. (1958). Proc. 4th int. Congr. Biochem., Vienna, 3, 213. Tsukada, Y., Nagata, Y. & Hirano, S. (1960). Nature, Lond., i86, 474. Vardanis, A. & Quastel, J. H. (1961). Canad. J. Biochem. Phy8iol. 39, 1811. Waelsch, H. (1958). Proc. 4th int. Congr. Biochem., Vienna, 3, 36. Weil-Malherbe, H. (1936). Biochem. J. 80, 665. Weil-Malherbe, H. (1938). Biochem. J. 32, 2257. Whittam, R. (1961). ...
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In idiopathic methaemoglobinaemia, of which we have investigated'some cases, the occurrence of an atypical form of methaemoglobin' abnormally resistant to reduction has been postulated by Lian, Frumusan & Sassier [1939] as an aetiological factor. It thus became of interest to examine the evidence which has been put forward by Vestling [1942] against the unitary view of methaemoglobin. This auth...
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A thiazine dye reductase has been described in endothelial cells that reduces methylene blue (MB), allowing its uptake into cells. Because a different mechanism of MB uptake in human erythrocytes has been proposed, we measured MB uptake and reduction in this cell type. Oxidized MB (MB(+)) stimulated reduction of extracellular ferricyanide in a time- and concentration-dependent manner, reflectin...
متن کامل[Regulation of methemoglobin reduction in human erythrocytes].
The regulation of methemoglobin reduction in human erythrocytes was studied in vitro in association with glycolytic reactions, by using hemolysates prepared from the nitrate-treated eryth rocytes. The results obtained are as follows; 1) The addition of cytochrome b5 to the reaction mixture containing fructose 1,6-diphosphate as the substrate for glycolysis caused a marked increase in...
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ژورنال
عنوان ژورنال: Biochemical Journal
سال: 1980
ISSN: 0306-3283
DOI: 10.1042/bj1880535